epoxide hydrolase 2, cytoplasmic

Symbol

EPHX2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Orthologs

Symbol	Species
ephx2	Danio rerio
Ephx2	Mus musculus
Ephx2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2635	Hypomethylation of EPHX2 is positively correlated with age	Molecular	blood	Human	EPHX2	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006805	xenobiotic metabolic process	biological_process
GO:0006874	cellular calcium ion homeostasis	biological_process
GO:0006954	inflammatory response	biological_process
GO:0008152	metabolic process	biological_process
GO:0008217	regulation of blood pressure	biological_process
GO:0009636	response to toxin	biological_process
GO:0017144	drug metabolic process	biological_process
GO:0019439	aromatic compound catabolic process	biological_process
GO:0045909	positive regulation of vasodilation	biological_process
GO:0072593	reactive oxygen species metabolic process	biological_process
GO:0005625	soluble fraction	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005777	peroxisome	cellular_component
GO:0005794	Golgi apparatus	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005925	focal adhesion	cellular_component
GO:0003824	catalytic activity	molecular_function
GO:0004301	epoxide hydrolase activity	molecular_function
GO:0016787	hydrolase activity	molecular_function
GO:0042803	protein homodimerization activity	molecular_function
GO:0046872	metal ion binding	molecular_function
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