ATP-binding cassette, sub-family A (ABC1), member 1

Symbol

ABCA1 (may also be known as: None)

Organism

Human

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
abca1b Danio rerio
Abca1 Mus musculus
Abca1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2966 Gene expression of ABCA1 increases with age Molecular skin Human ABCA1 —

GO Terms

GO IDGO TermGO Category
GO:0002790 peptide secretion biological_process
GO:0006497 protein lipidation biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006810 transport biological_process
GO:0006820 anion transport biological_process
GO:0006911 phagocytosis, engulfment biological_process
GO:0007040 lysosome organization biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0008202 steroid metabolic process biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0010745 negative regulation of macrophage derived foam cell differentiation biological_process
GO:0010875 positive regulation of cholesterol efflux biological_process
GO:0010887 negative regulation of cholesterol storage biological_process
GO:0016197 endosome transport biological_process
GO:0030819 positive regulation of cAMP biosynthetic process biological_process
GO:0032367 intracellular cholesterol transport biological_process
GO:0032488 Cdc42 protein signal transduction biological_process
GO:0033344 cholesterol efflux biological_process
GO:0033700 phospholipid efflux biological_process
GO:0034380 high-density lipoprotein particle assembly biological_process
GO:0034616 response to laminar fluid shear stress biological_process
GO:0038027 apolipoprotein A-I-mediated signaling pathway biological_process
GO:0042157 lipoprotein metabolic process biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0043691 reverse cholesterol transport biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045332 phospholipid translocation biological_process
GO:0050702 interleukin-1 beta secretion biological_process
GO:0055091 phospholipid homeostasis biological_process
GO:0055098 response to low-density lipoprotein particle stimulus biological_process
GO:0060155 platelet dense granule organization biological_process
GO:0071222 cellular response to lipopolysaccharide biological_process
GO:0071300 cellular response to retinoic acid biological_process
GO:0005622 intracellular cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0030139 endocytic vesicle cellular_component
GO:0045121 membrane raft cellular_component
GO:0045335 phagocytic vesicle cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0005543 phospholipid binding molecular_function
GO:0005548 phospholipid transporter activity molecular_function
GO:0008509 anion transmembrane transporter activity molecular_function
GO:0015485 cholesterol binding molecular_function
GO:0016887 ATPase activity molecular_function
GO:0017127 cholesterol transporter activity molecular_function
GO:0019905 syntaxin binding molecular_function
GO:0031267 small GTPase binding molecular_function
GO:0034185 apolipoprotein binding molecular_function
GO:0034186 apolipoprotein A-I binding molecular_function
GO:0034188 apolipoprotein A-I receptor activity molecular_function