distal-less homeobox 5


DLX5 (may also be known as: None)




This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]


dlx5a Danio rerio
Dlx5 Mus musculus
Dlx5 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0001649 osteoblast differentiation biological_process
GO:0001958 endochondral ossification biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007399 nervous system development biological_process
GO:0007411 axon guidance biological_process
GO:0008283 cell proliferation biological_process
GO:0030326 embryonic limb morphogenesis biological_process
GO:0030855 epithelial cell differentiation biological_process
GO:0042305 specification of segmental identity, mandibular segment biological_process
GO:0042472 inner ear morphogenesis biological_process
GO:0043583 ear development biological_process
GO:0045669 positive regulation of osteoblast differentiation biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048646 anatomical structure formation involved in morphogenesis biological_process
GO:0050679 positive regulation of epithelial cell proliferation biological_process
GO:0060021 palate development biological_process
GO:0060166 olfactory pit development biological_process
GO:0060322 head development biological_process
GO:0060325 face morphogenesis biological_process
GO:0060349 bone morphogenesis biological_process
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0000976 transcription regulatory region sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0071837 HMG box domain binding molecular_function