distal-less homeobox 5

Symbol

DLX5 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
dlx5a Danio rerio
Dlx5 Mus musculus
Dlx5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2706 Hypermethylation of DLX5 is positively correlated with age Molecular blood Human DLX5 —

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0001649 osteoblast differentiation biological_process
GO:0001958 endochondral ossification biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007399 nervous system development biological_process
GO:0007411 axon guidance biological_process
GO:0008283 cell proliferation biological_process
GO:0030326 embryonic limb morphogenesis biological_process
GO:0030855 epithelial cell differentiation biological_process
GO:0042305 specification of segmental identity, mandibular segment biological_process
GO:0042472 inner ear morphogenesis biological_process
GO:0043583 ear development biological_process
GO:0045669 positive regulation of osteoblast differentiation biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048646 anatomical structure formation involved in morphogenesis biological_process
GO:0050679 positive regulation of epithelial cell proliferation biological_process
GO:0060021 palate development biological_process
GO:0060166 olfactory pit development biological_process
GO:0060322 head development biological_process
GO:0060325 face morphogenesis biological_process
GO:0060349 bone morphogenesis biological_process
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0000976 transcription regulatory region sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0071837 HMG box domain binding molecular_function