distal-less homeobox 5

Symbol

DLX5 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
dlx5a	Danio rerio
Dlx5	Mus musculus
Dlx5	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2706	Hypermethylation of DLX5 is positively correlated with age	Molecular	blood	Human	DLX5	—

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GO Terms

GO ID	GO Term	GO Category
GO:0001501	skeletal system development	biological_process
GO:0001649	osteoblast differentiation	biological_process
GO:0001958	endochondral ossification	biological_process
GO:0007275	multicellular organismal development	biological_process
GO:0007399	nervous system development	biological_process
GO:0007411	axon guidance	biological_process
GO:0008283	cell proliferation	biological_process
GO:0030326	embryonic limb morphogenesis	biological_process
GO:0030855	epithelial cell differentiation	biological_process
GO:0042305	specification of segmental identity, mandibular segment	biological_process
GO:0042472	inner ear morphogenesis	biological_process
GO:0043583	ear development	biological_process
GO:0045669	positive regulation of osteoblast differentiation	biological_process
GO:0045893	positive regulation of transcription, DNA-dependent	biological_process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_process
GO:0048646	anatomical structure formation involved in morphogenesis	biological_process
GO:0050679	positive regulation of epithelial cell proliferation	biological_process
GO:0060021	palate development	biological_process
GO:0060166	olfactory pit development	biological_process
GO:0060322	head development	biological_process
GO:0060325	face morphogenesis	biological_process
GO:0060349	bone morphogenesis	biological_process
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	biological_process
GO:0005634	nucleus	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0000976	transcription regulatory region sequence-specific DNA binding	molecular_function
GO:0044212	transcription regulatory region DNA binding	molecular_function
GO:0071837	HMG box domain binding	molecular_function
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