EDAR-associated death domain

Symbol

EDARADD (may also be known as: None)

Organism

Human

Description

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
edaradd Danio rerio
Edaradd Mus musculus
Edaradd Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001942 hair follicle development biological_process
GO:0007165 signal transduction biological_process
GO:0007275 multicellular organismal development biological_process
GO:0030154 cell differentiation biological_process
GO:0042475 odontogenesis of dentin-containing tooth biological_process
GO:0061153 trachea gland development biological_process
GO:0005737 cytoplasm cellular_component