chloride channel, voltage-sensitive 6
Symbol
CLCN6
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| clcn6 | Danio rerio | |
| Clcn6 | Mus musculus | |
| Clcn6 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006811 | ion transport | biological_process | |
| GO:0006821 | chloride transport | biological_process | |
| GO:0006884 | cell volume homeostasis | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0055085 | transmembrane transport | biological_process | |
| GO:0005768 | endosome | cellular_component | |
| GO:0010008 | endosome membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0005216 | ion channel activity | molecular_function | |
| GO:0005247 | voltage-gated chloride channel activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0015297 | antiporter activity | molecular_function | |