meningioma expressed antigen 5 (hyaluronidase)
Symbol
MGEA5
(may also be known as: None)
Organism
Human
Description
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| oga-1 | Caenorhabditis elegans | |
| Oga | Drosophila melanogaster | |
| mgea5 | Danio rerio | |
| Mgea5 | Mus musculus | |
| Mgea5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006044 | N-acetylglucosamine metabolic process | biological_process | |
| GO:0006516 | glycoprotein catabolic process | biological_process | |
| GO:0006612 | protein targeting to membrane | biological_process | |
| GO:0007568 | aging | biological_process | |
| GO:0010524 | positive regulation of calcium ion transport into cytosol | biological_process | |
| GO:0010616 | negative regulation of cardiac muscle adaptation | biological_process | |
| GO:0031343 | positive regulation of cell killing | biological_process | |
| GO:0032024 | positive regulation of insulin secretion | biological_process | |
| GO:0043243 | positive regulation of protein complex disassembly | biological_process | |
| GO:0045862 | positive regulation of proteolysis | biological_process | |
| GO:0046060 | dATP metabolic process | biological_process | |
| GO:0046326 | positive regulation of glucose import | biological_process | |
| GO:0048545 | response to steroid hormone stimulus | biological_process | |
| GO:0051054 | positive regulation of DNA metabolic process | biological_process | |
| GO:0051901 | positive regulation of mitochondrial depolarization | biological_process | |
| GO:0060051 | negative regulation of protein glycosylation | biological_process | |
| GO:0060124 | positive regulation of growth hormone secretion | biological_process | |
| GO:0070265 | necrotic cell death | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0004402 | histone acetyltransferase activity | molecular_function | |
| GO:0004415 | hyalurononglucosaminidase activity | molecular_function | |
| GO:0016746 | transferase activity, transferring acyl groups | molecular_function | |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | molecular_function | |