meningioma expressed antigen 5 (hyaluronidase)

Symbol

MGEA5 (may also be known as: None)

Organism

Human

Description

The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

Orthologs

Symbol	Species
oga-1	Caenorhabditis elegans
Oga	Drosophila melanogaster
mgea5	Danio rerio
Mgea5	Mus musculus
Mgea5	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2622	Hypomethylation of MGEA5 is positively correlated with age	Molecular	blood	Human	MGEA5	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006044	N-acetylglucosamine metabolic process	biological_process
GO:0006516	glycoprotein catabolic process	biological_process
GO:0006612	protein targeting to membrane	biological_process
GO:0007568	aging	biological_process
GO:0010524	positive regulation of calcium ion transport into cytosol	biological_process
GO:0010616	negative regulation of cardiac muscle adaptation	biological_process
GO:0031343	positive regulation of cell killing	biological_process
GO:0032024	positive regulation of insulin secretion	biological_process
GO:0043243	positive regulation of protein complex disassembly	biological_process
GO:0045862	positive regulation of proteolysis	biological_process
GO:0046060	dATP metabolic process	biological_process
GO:0046326	positive regulation of glucose import	biological_process
GO:0048545	response to steroid hormone stimulus	biological_process
GO:0051054	positive regulation of DNA metabolic process	biological_process
GO:0051901	positive regulation of mitochondrial depolarization	biological_process
GO:0060051	negative regulation of protein glycosylation	biological_process
GO:0060124	positive regulation of growth hormone secretion	biological_process
GO:0070265	necrotic cell death	biological_process
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0004402	histone acetyltransferase activity	molecular_function
GO:0004415	hyalurononglucosaminidase activity	molecular_function
GO:0016746	transferase activity, transferring acyl groups	molecular_function
GO:0016798	hydrolase activity, acting on glycosyl bonds	molecular_function
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