insulin-like growth factor 2 mRNA binding protein 1

Symbol

IGF2BP1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Orthologs

SymbolSpecies
igf2bp1 Danio rerio
Igf2bp1 Mus musculus
Igf2bp1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2726 Hypermethylation of IGF2BP1 is positively correlated with age Molecular blood Human IGF2BP1 —

GO Terms

GO IDGO TermGO Category
GO:0006403 RNA localization biological_process
GO:0010610 regulation of mRNA stability involved in response to stress biological_process
GO:0017148 negative regulation of translation biological_process
GO:0042035 regulation of cytokine biosynthetic process biological_process
GO:0070934 CRD-mediated mRNA stabilization biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0010494 cytoplasmic stress granule cellular_component
GO:0030027 lamellipodium cellular_component
GO:0030529 ribonucleoprotein complex cellular_component
GO:0043197 dendritic spine cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0070937 CRD-mediated mRNA stability complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003723 RNA binding molecular_function
GO:0003729 mRNA binding molecular_function
GO:0003730 mRNA 3'-UTR binding molecular_function
GO:0005515 protein binding molecular_function
GO:0045182 translation regulator activity molecular_function
GO:0048027 mRNA 5'-UTR binding molecular_function