insulin-like growth factor 2 mRNA binding protein 1

Symbol

IGF2BP1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Orthologs

Symbol	Species
igf2bp1	Danio rerio
Igf2bp1	Mus musculus
Igf2bp1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2726	Hypermethylation of IGF2BP1 is positively correlated with age	Molecular	blood	Human	IGF2BP1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006403	RNA localization	biological_process
GO:0010610	regulation of mRNA stability involved in response to stress	biological_process
GO:0017148	negative regulation of translation	biological_process
GO:0042035	regulation of cytokine biosynthetic process	biological_process
GO:0070934	CRD-mediated mRNA stabilization	biological_process
GO:0005634	nucleus	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0010494	cytoplasmic stress granule	cellular_component
GO:0030027	lamellipodium	cellular_component
GO:0030529	ribonucleoprotein complex	cellular_component
GO:0043197	dendritic spine	cellular_component
GO:0043231	intracellular membrane-bounded organelle	cellular_component
GO:0070937	CRD-mediated mRNA stability complex	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0003723	RNA binding	molecular_function
GO:0003729	mRNA binding	molecular_function
GO:0003730	mRNA 3'-UTR binding	molecular_function
GO:0005515	protein binding	molecular_function
GO:0045182	translation regulator activity	molecular_function
GO:0048027	mRNA 5'-UTR binding	molecular_function
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