importin 8
Symbol
IPO8
(may also be known as: None)
Organism
Human
Description
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| msk | Drosophila melanogaster | |
| ipo8 | Danio rerio | |
| Ipo8 | Mus musculus | |
| NMD5 | Saccharomyces cerevisiae | |
| SPCC550.11 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005488 | binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008536 | Ran GTPase binding | molecular_function | |
| GO:0008565 | protein transporter activity | molecular_function | |