DLC1 Rho GTPase activating protein


DLC1 (may also be known as: None)




This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]


uncharacterized_E7FB Danio rerio
Dlc1 Mus musculus
Dlc1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001843 neural tube closure biological_process
GO:0003007 heart morphogenesis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0007165 signal transduction biological_process
GO:0007202 activation of phospholipase C activity biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008360 regulation of cell shape biological_process
GO:0021575 hindbrain morphogenesis biological_process
GO:0030036 actin cytoskeleton organization biological_process
GO:0030336 negative regulation of cell migration biological_process
GO:0030900 forebrain development biological_process
GO:0032321 positive regulation of Rho GTPase activity biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0032956 regulation of actin cytoskeleton organization biological_process
GO:0035024 negative regulation of Rho protein signal transduction biological_process
GO:0035307 positive regulation of protein dephosphorylation biological_process
GO:0048041 focal adhesion assembly biological_process
GO:0051056 regulation of small GTPase mediated signal transduction biological_process
GO:0051497 negative regulation of stress fiber assembly biological_process
GO:0001725 stress fiber cellular_component
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005884 actin filament cellular_component
GO:0005901 caveola cellular_component
GO:0005925 focal adhesion cellular_component
GO:0045121 membrane raft cellular_component
GO:0005096 GTPase activator activity molecular_function
GO:0005100 Rho GTPase activator activity molecular_function
GO:0005515 protein binding molecular_function
GO:0017166 vinculin binding molecular_function
GO:0030675 Rac GTPase activator activity molecular_function
GO:0042169 SH2 domain binding molecular_function
GO:0043274 phospholipase binding molecular_function