DLC1 Rho GTPase activating protein

Symbol

DLC1 (may also be known as: None)

Organism

Human

Description

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

Orthologs

Symbol	Species
uncharacterized_E7FB	Danio rerio
Dlc1	Mus musculus
Dlc1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2655	Hypermethylation of DLC1 is positively correlated with age	Molecular	blood	Human	DLC1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0001843	neural tube closure	biological_process
GO:0003007	heart morphogenesis	biological_process
GO:0006917	induction of apoptosis	biological_process
GO:0006919	activation of caspase activity	biological_process
GO:0007165	signal transduction	biological_process
GO:0007202	activation of phospholipase C activity	biological_process
GO:0007264	small GTPase mediated signal transduction	biological_process
GO:0008285	negative regulation of cell proliferation	biological_process
GO:0008360	regulation of cell shape	biological_process
GO:0021575	hindbrain morphogenesis	biological_process
GO:0030036	actin cytoskeleton organization	biological_process
GO:0030336	negative regulation of cell migration	biological_process
GO:0030900	forebrain development	biological_process
GO:0032321	positive regulation of Rho GTPase activity	biological_process
GO:0032869	cellular response to insulin stimulus	biological_process
GO:0032956	regulation of actin cytoskeleton organization	biological_process
GO:0035024	negative regulation of Rho protein signal transduction	biological_process
GO:0035307	positive regulation of protein dephosphorylation	biological_process
GO:0048041	focal adhesion assembly	biological_process
GO:0051056	regulation of small GTPase mediated signal transduction	biological_process
GO:0051497	negative regulation of stress fiber assembly	biological_process
GO:0001725	stress fiber	cellular_component
GO:0005622	intracellular	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005884	actin filament	cellular_component
GO:0005901	caveola	cellular_component
GO:0005925	focal adhesion	cellular_component
GO:0045121	membrane raft	cellular_component
GO:0005096	GTPase activator activity	molecular_function
GO:0005100	Rho GTPase activator activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0017166	vinculin binding	molecular_function
GO:0030675	Rac GTPase activator activity	molecular_function
GO:0042169	SH2 domain binding	molecular_function
GO:0043274	phospholipase binding	molecular_function
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