poly (ADP-ribose) polymerase family, member 3
Symbol
PARP3
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| parp3 | Danio rerio | |
| Parp3 | Mus musculus | |
| Parp3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006281 | DNA repair | biological_process | |
| GO:0006471 | protein ADP-ribosylation | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005814 | centriole | cellular_component | |
| GO:0005815 | microtubule organizing center | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0003824 | catalytic activity | molecular_function | |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | molecular_function | |
| GO:0016757 | transferase activity, transferring glycosyl groups | molecular_function | |