Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (PubMed) (248 entries)

Changes associated with this reference

Identifier Name Type Tissues Organism Gene Data Actions
DAA2308 chemokine (C-X3-C motif) ligand 1 decreases with age Molecular frontal lobe Human CX3CL1 58.0% Decrease Gene Expression Level
DAA2236 CD14 molecule increases with age Molecular frontal lobe Human CD14 134.9% Increase Gene Expression Level
DAA2325 major histocompatibility complex, class II, DP alpha 1 increases with age Molecular frontal lobe Human HLA-DPA1 97.1% Increase Gene Expression Level
DAA2342 major histocompatibility complex, class I, C increases with age Molecular frontal lobe Human HLA-C 40.1% Increase Gene Expression Level
DAA2240 toll-like receptor 4 increases with age Molecular frontal lobe Human TLR4 83.7% Increase Gene Expression Level
DAA2382 major histocompatibility complex, class I, C increases with age Molecular frontal lobe Human HLA-C 44.0% Increase Gene Expression Level
DAA2379 major histocompatibility complex, class I, B increases with age Molecular frontal lobe Human HLA-B 39.0% Increase Gene Expression Level
DAA2288 CD163 molecule increases with age Molecular frontal lobe Human CD163 383.1% Increase Gene Expression Level
DAA2368 major histocompatibility complex, class II, DP beta 1 increases with age Molecular frontal lobe Human HLA-DPB1 76.9% Increase Gene Expression Level
DAA2341 major histocompatibility complex, class I, B increases with age Molecular frontal lobe Human HLA-B 36.5% Increase Gene Expression Level
DAA2235 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 36.3% Decrease Gene Expression Level
DAA2347 HLA-G histocompatibility antigen, class I, G increases with age Molecular frontal lobe Human HLA-G 28.4% Increase Gene Expression Level
DAA2294 Fc fragment of IgG, receptor, transporter, alpha increases with age Molecular frontal lobe Human FCGRT 89.3% Increase Gene Expression Level
DAA2293 Fc fragment of IgG, low affinity IIIb, receptor (CD16b) increases with age Molecular frontal lobe Human FCGR3B 52.1% Increase Gene Expression Level
DAA2233 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 59.5% Decrease Gene Expression Level
DAA2162 Fc fragment of IgG, low affinity IIIb, receptor (CD16b) increases with age Molecular frontal lobe Human FCGR3B 261.1% Increase Gene Expression Level
DAA2292 Fc fragment of IgG, low affinity IIa, receptor (CD32) increases with age Molecular frontal lobe Human FCGR2A 104.3% Increase Gene Expression Level
DAA2326 major histocompatibility complex, class II, DR alpha increases with age Molecular frontal lobe Human HLA-DRA 146.8% Increase Gene Expression Level
DAA2145 Fc fragment of IgG, high affinity Ib, receptor (CD64) increases with age Molecular frontal lobe Human FCGR1B 170.4% Increase Gene Expression Level
DAA2234 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 57.8% Decrease Gene Expression Level
DAA2369 major histocompatibility complex, class II, DR alpha increases with age Molecular frontal lobe Human HLA-DRA 135.3% Increase Gene Expression Level
DAA2144 Fc fragment of IgG, high affinity Ia, receptor (CD64) increases with age Molecular frontal lobe Human FCGR1A 157.3% Increase Gene Expression Level
DAA2137 major histocompatibility complex, class II, DR beta 1 increases with age Molecular frontal lobe Human HLA-DRB1 83.0% Increase Gene Expression Level