| DAA940 |
B naive cells' susceptibility to apoptosis decreases |
Physiological |
memory B cell |
Human |
— |
— |
|
| DAA972 |
Chemotaxis and adhesion activity unchanged in vitro |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA968 |
Chronic inflammation increases |
Physiological |
blood, immune system |
Human |
— |
— |
|
| DAA949 |
Cytomegalovirus infection incidence increases |
Pathological |
immune system |
Human |
— |
— |
|
| DAA986 |
Cytotoxicity and interleukin-2 response of natural killer cells decreases |
Physiological |
natural killer cell |
Human |
— |
— |
|
| DAA1229 |
Declining T-lymphocyte production in the thymus |
Physiological |
thymus |
Human |
— |
— |
|
| DAA991 |
Decreased function of epithelial barriers |
Physiological |
lung, oral cavity, pharynx, oesophagus, stomach, intestine, epidermis |
Human |
— |
— |
|
| DAA983 |
Diminished superoxide production in response to Fc |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA963 |
Expansion into effector cells is reduced |
Physiological |
naïve T cell |
Human |
— |
— |
|
| DAA985 |
Functional decline and decreases in macrophage numbers in bone marrow |
Physiological |
macrophage |
Human |
— |
— |
|
| DAA988 |
Function declines |
Physiological |
dendritic cell |
Mouse |
— |
— |
|
| DAA950 |
Immune response to Epstein-Barr virus decreases in cytomegalovirus positive individuals |
Physiological |
immune system |
Human |
— |
— |
|
| DAA987 |
Increase in total number of cells |
Physiological |
natural killer cell |
Human |
— |
— |
|
| DAA962 |
Interleukin-2 production in response to influenza vaccine declines |
Physiological |
T cell |
Human |
IL2 |
— |
|
| DAA943 |
Lower affinity antibodies generated |
Physiological |
B cell |
Mouse |
— |
— |
|
| DAA939 |
Naive cell number increases and memory cells decrease |
Physiological |
B cell |
Human |
— |
— |
|
| DAA933 |
No changes in erythroid and myeloid progenitor cells evident |
Physiological |
myeloid progenitor cell |
Human |
— |
— |
|
| DAA934 |
Number of mature B cells leaving the bone marrow declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
| DAA980 |
Phagocytosis activity decreased in response to opsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA981 |
Phagocytosis activity unchanged in response to unopsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA935 |
Pro-B cell generation and differentiation declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
| DAA960 |
Receptor expression alterations |
Physiological |
grey matter |
Human |
— |
— |
|
| DAA932 |
Renewal capacity declines |
Physiological |
hematopoietic stem cells |
Human |
— |
— |
|
| DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|
| DAA959 |
telomere shortening |
Molecular |
naïve T cell |
Human |
— |
— |
|