Immune System

Synonyms

immunity

Description

An immune system is a system of biological structures and processes within an organism that protects against disease. In order to function properly, an immune system must detect a wide variety of agents, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue [Source: Wikipedia].

Structure

Changes associated with this tissue

Due to the potentially large amount of high-throughput molecular changes these have been excluded below. You can view the full list of 99 changes through the filter results page.

Physiological (38) View on results page

Apoptotic pathway in response to stimuli disrupted B naive cells' susceptibility to apoptosis decreases Chemotaxis and adhesion activity unchanged in vitro Chemotaxis and respiratory burst capacity in response to GM-CSF priming decreased Chemotaxis is reduced Chronic inflammation increases Cytotoxicity and interleukin-2 response of natural killer cells decreases Declining T-lymphocyte production in the thymus Diminished superoxide production in response to Fc E-rosette-forming cells decrease Expansion into effector cells is reduced Fewer CD4+ and CD8+ cells Functional decline and decreases in macrophage numbers in bone marrow Function declines Immune response to Epstein-Barr virus decreases in cytomegalovirus positive individuals Incidence of anergia increases Increase in cells that are both CD8+ and CD28-null Increase in total number of cells Infiltration at injury site is reduced Interleukin-6 plasma levels are elevated in response to acute systemic inflammation Less antibodies generated Lower affinity antibodies generated Naive cell number increases and memory cells decrease Number of mature B cells leaving the bone marrow declines Number of T cell progenitors declines Phagocytosis activity decreased in response to opsonized targets Phagocytosis activity unchanged in response to unopsonized targets Pro-B cell generation and differentiation declines Proliferation is reduced ROS production in response to stimuli unchanged Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione Spontaneous production of superoxide decreased T-cell diversity declines Telomere shortening Thymus involution Vaccination antibody response is impaired Vitamin C levels decrease Volume of perivascular space around thymus increases

Molecular (5; 55 in total) View on results page

Changes from high-throughput approaches are excluded but can be viewed on the results page.

decreased NF-KappaB induction in T cells decreased proteasomal activity in T cells telomere shortening telomere shortening telomere shortening

Pathological (1) View on results page

Cytomegalovirus infection incidence increases