Musculoskeletal System

Description

A musculoskeletal system (also known as the locomotor system) is an organ system that gives animals (including humans) the ability to move using the muscular and skeletal systems. The musculoskeletal system provides form, support, stability, and movement to the body [Source: Wikipedia].

Structure

Changes associated with this tissue

Due to the potentially large amount of high-throughput molecular changes these have been excluded below. You can view the full list of 531 changes through the filter results page.

Physiological (46) View on results page

Advanced glycation end products increases in aging human skeletal muscle Bone becomes more brittle, less flexible Bone density of total hip and femoral neck decreases Bone loss Bone mass decreases Bone mineral density in cortical ulna decreases Bone porosity increases Bone remodeling decreases Bone resorption increases for cortical bone Calcification makes cartilage more brittle Calcification of cartilage matrix Calcification of costal cartilage Cartilage asbestos transformation€ Cartilage calcification interferes with normal diffusion metabolism Cartilage color changes Cartilage joint surface cracks and frays Cartilage matrix softening and cavity formation Cartilage matrix synthesis to degradation ratio decreases Cartilage resiliency decreases Cell number decreases in cartilage Chondroitin sulfate molecules are smaller Chondroitin sulfate molecules' water-binding capacity is decreased Decline in respiratory muscle fibers Fibril types in cartilage matrix are altered Fractures are cleaner Grip strength decreases Grip strength decreases Interleukin-15 levels decrease in plasma and muscle Joint cushioning reduced Loss of muscle torque Loss of peripheral motor neurons Mineralization of bone tissue increases Motor coordination decreases Muscle atrophy (sarcopenia) Muscle characteristics change with aging Muscle fiber energy metabolism declines Muscle mass and strength loss Mutations in mitochondrial DNA accumulate Osteoporosis: progressive loss of bone strength Proteoglycan alterations in cartilage Reduced type II muscle fiber Respiratory muscle strength declines Synovial fluid alterations Telomere shortening Tendons' ability to elongate decreases Weaker digestive tract muscle contractions

Molecular (2; 479 in total) View on results page

Changes from high-throughput approaches are excluded but can be viewed on the results page.

MicroRNA let-7b expression upregulated MicroRNA let-7e expression upregulated

Pathological (4) View on results page

Arthritis (Female) Arthritis (Male) Hip fracture risk increases Osteoarthritis