Bone Marrow

Description

The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells [Source: Brenda].

Structure

Changes associated with this tissue

Due to the potentially large amount of high-throughput molecular changes these have been excluded below. You can view the full list of 51 changes through the filter results page.

Physiological (14) View on results page

Adipocyte formation increases Alterations in frequency, developmental potential and gene expression profile in hematopoietic stem cells Beta-galactosidase expression increases in mesenchymal stem cells Capacity of mesenchymal stem cells to differentiate into osteoblasts may be decreased DNA damage acummulates in hematopoietic stem and progenitor cells Fewer cells and higher apoptosis Hematopoietic cells accumulate random mutations Number and differentiation potential of adipose tissue-derived stem cells declines with age Number of mature B cells leaving the bone marrow declines Osteoblast differentiation decreases Pro-B cell generation and differentiation declines Proliferation rate of mesenchymal stem cells is reduced Renewal capacity declines Volume of hematopoietic bone marrow decreases

Molecular (2; 35 in total) View on results page

Changes from high-throughput approaches are excluded but can be viewed on the results page.

Intracellular NAD+ concentration decreases telomere length in hematopoietic stem cells