| DAA1000 |
Decline in epidermis keratinocyte turnover |
— |
epidermis |
Human |
|
| DAA1001 |
Atrophy of hypodermal layer |
— |
subcutaneous |
Human |
|
| DAA1002 |
Decreased ability to modulate heat loss |
— |
integument system |
Human |
|
| DAA1003 |
Wrinkles |
— |
skin |
Human |
|
| DAA1004 |
Decreased/disorganized fibril network of dermis |
— |
dermis |
Human |
|
| DAA1005 |
Loss of smooth padding provided by hypodermal fat cells |
— |
skin |
Human |
|
| DAA1006 |
Decreased amounts of collagen IV and VII, and abnormal elastin in dermis |
— |
dermis |
Human |
|
| DAA1009 |
Dermal collagen atrophies |
— |
dermis |
Human |
|
| DAA1011 |
Changes in glycosaminoglycan/proteoglycan |
— |
epidermis, dermis |
Human |
|
| DAA1052 |
Cholesterol level - High (Male) |
SeriesIncidence |
plasma |
Human |
|
| DAA1053 |
Cholesterol level - High (Female) |
SeriesIncidence |
plasma |
Human |
|
| DAA1057 |
Lean body mass decreases |
— |
whole body |
Human |
|
| DAA1058 |
Body fat increases |
— |
whole body |
Human |
|
| DAA1060 |
Blood flow to liver decreases |
— |
liver |
Human |
|
| DAA1061 |
Variability in clearance of hepatically metabolized drugs |
— |
liver |
Human |
|
| DAA1062 |
Creatinine clearance declines |
— |
kidney |
Human |
|
| DAA1063 |
Orthostatic hypotension incidence increases |
— |
cardiovascular system |
Human |
|
| DAA1073 |
Fewer cells and higher apoptosis |
— |
bone marrow |
Human |
|
| DAA1076 |
Progressive liquefaction |
— |
vitreous humor |
Human |
|
| DAA1180 |
Morning concentrations of testosterone decline |
80.0% Decrease Hormone Level |
plasma |
Human |
|
| DAA1181 |
Morning IGF1 decline |
51.0% Decrease Hormone Level |
plasma |
Human |
|
| DAA1198 |
Circadian Rhythm |
— |
whole body |
Human |
|
| DAA1199 |
Serum klotho |
Increase Hormone Level |
plasma |
Human |
|
| DAA1200 |
Inhibin levels decline |
Decrease Hormone Level |
plasma |
Human |
|
| DAA1205 |
Body temperature decreases with age |
— |
whole body |
Human |
|