DAA954 |
Number of T cell progenitors declines |
Physiological |
T cell progenitor |
Human |
— |
— |
|
DAA980 |
Phagocytosis activity decreased in response to opsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA981 |
Phagocytosis activity unchanged in response to unopsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA935 |
Pro-B cell generation and differentiation declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
DAA956 |
Proliferation is reduced |
Physiological |
lymphocytes |
Human |
— |
— |
|
DAA977 |
ROS production in response to stimuli unchanged |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA984 |
Spontaneous production of superoxide decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|
DAA1986 |
telomere shortening |
Molecular |
leukocyte |
Human |
— |
— |
|
DAA959 |
telomere shortening |
Molecular |
naïve T cell |
Human |
— |
— |
|
DAA989 |
telomere shortening |
Molecular |
lymphocytes |
Human |
— |
— |
|
DAA2599 |
Telomere shortening |
Physiological |
adipose tissue, skeletal muscle, skin, leukocyte |
Human |
— |
— |
|
DAA945 |
Thymus involution |
Physiological |
thymus |
Human |
— |
— |
|
DAA966 |
Vaccination antibody response is impaired |
Physiological |
immune system |
Human |
— |
— |
|
DAA948 |
Volume of perivascular space around thymus increases |
Physiological |
thymus |
Human |
— |
— |
|
DAA2034 |
Expression of WRN decreases |
Molecular |
blood, immune system |
Human |
WRN |
52.0% Decrease Gene Expression Level |
|
DAA1987 |
Loss of CpG methylation in the promoter of TNF |
Molecular |
macrophage, leukocyte |
Human |
TNF |
— |
|
DAA1987 |
Loss of CpG methylation in the promoter of TNF |
Molecular |
macrophage, leukocyte |
Human |
TNF |
— |
|
DAA2561 |
Level of let-7i decreases with age |
Molecular |
T cell |
Human |
MIRLET7I |
46.9% Decrease miRNA Level |
|
DAA2559 |
Level of let-7f decreases with age |
Molecular |
T cell |
Human |
MIRLET7F1 |
65.6% Decrease miRNA Level |
|
DAA2577 |
Level of let-7c increases with age |
Molecular |
T cell |
Human |
MIRLET7C |
33.6% Increase miRNA Level |
|
DAA2576 |
Level of miR-98 decreases with age |
Molecular |
T cell |
Human |
MIR98 |
43.8% Decrease miRNA Level |
|
DAA2554 |
Level of miR-668 increases with age |
Molecular |
T cell |
Human |
MIR668 |
251.4% Increase miRNA Level |
|
DAA2570 |
Level of miR-590-5p decreases with age |
Molecular |
T cell |
Human |
MIR590 |
55.8% Decrease miRNA Level |
|
DAA2562 |
Level of miR-525-5p decreases with age |
Molecular |
T cell |
Human |
MIR525 |
61.4% Decrease miRNA Level |
|