| DAA714 |
Neuronal soma shrinks in size |
Physiological |
brain |
Human |
— |
— |
|
| DAA717 |
Dendrite regression, reduction in dendrite length |
Physiological |
brain |
Human |
— |
— |
|
| DAA718 |
Synaptic density slightly decreases at advanced ages |
Physiological |
frontal lobe |
Human |
— |
— |
|
| DAA72 |
eukaryotic translation initiation factor 4A, isoform 2 |
Molecular |
brain |
Human |
EIF4A2 |
3.0% Decrease Gene Expression Level |
|
| DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
Physiological |
brain |
Human |
— |
— |
|
| DAA722 |
Accumulation of neuromelanin in dopaminergic nigral neurons |
Physiological |
substantia nigra |
Human |
— |
— |
|
| DAA723 |
Accumulation of extracellular neuritic plaques |
Physiological |
brain |
Human |
— |
— |
|
| DAA724 |
Global neuron loss |
Physiological |
cerebral cortex |
Human |
— |
— |
|
| DAA725 |
Leukoaraiosis |
Physiological |
white matter |
Human |
— |
— |
|
| DAA726 |
Demyelination |
Physiological |
white matter |
Human |
— |
— |
|
| DAA727 |
Axon loss |
Physiological |
white matter |
Human |
— |
— |
|
| DAA728 |
Brain matter volume declines |
Physiological |
brain |
Human |
— |
— |
|
| DAA729 |
Gray matter volume decreases |
Physiological |
grey matter |
Human |
— |
— |
|
| DAA73 |
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) |
Molecular |
brain |
Human |
ELAVL1 |
69.0% Decrease Gene Expression Level |
|
| DAA730 |
White matter volume decreases |
Physiological |
white matter |
Human |
— |
— |
|
| DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
| DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
| DAA732 |
Glial cell number |
Physiological |
cerebral cortex |
Human |
— |
— |
|
| DAA733 |
Neurotransmitter and neuro receptor concentrations are altered |
Physiological |
brain |
Human |
— |
— |
|
| DAA735 |
Localized increases and decreases in synaptic transmission |
Physiological |
brain |
Human |
— |
— |
|
| DAA737 |
Permeability increases with age |
Physiological |
blood brain barrier |
Human |
— |
— |
|
| DAA738 |
Cerebral spinal fluid amount increases |
Physiological |
brain |
Human |
— |
— |
|
| DAA739 |
Degeneration of dopamine neurons and receptors |
Physiological |
brain |
Human |
— |
— |
|
| DAA74 |
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) |
Molecular |
brain |
Human |
ELAVL2 |
10.0% Decrease Gene Expression Level |
|
| DAA740 |
Cortical plasticity decreases |
Physiological |
brain |
Human |
— |
— |
|