IQ motif containing B1


IQCB1 (may also be known as: None)




This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]


iqcb1 Danio rerio
Iqcb1 Mus musculus
Iqcb1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0042384 cilium assembly biological_process
GO:0045494 photoreceptor cell maintenance biological_process
GO:0048496 maintenance of organ identity biological_process
GO:0001750 photoreceptor outer segment cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0032391 photoreceptor connecting cilium cellular_component
GO:0005515 protein binding molecular_function
GO:0005516 calmodulin binding molecular_function