CD34 molecule

Symbol

CD34 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Orthologs

Symbol	Species
Cd34	Mus musculus
Cd34	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2406	CD34 antigen isoform b decreases with age	Molecular	dermis	Human	CD34	16.6% Decrease DNA Methylation
DAA2455	CD34 antigen isoform b decreases with age	Molecular	mesenchymal stem cell	Human	CD34	17.3% Decrease DNA Methylation

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GO Terms

GO ID	GO Term	GO Category
GO:0001894	tissue homeostasis	biological_process
GO:0001935	endothelial cell proliferation	biological_process
GO:0003094	glomerular filtration	biological_process
GO:0003158	endothelium development	biological_process
GO:0006536	glutamate metabolic process	biological_process
GO:0007155	cell adhesion	biological_process
GO:0007165	signal transduction	biological_process
GO:0008217	regulation of blood pressure	biological_process
GO:0008283	cell proliferation	biological_process
GO:0010628	positive regulation of gene expression	biological_process
GO:0010629	negative regulation of gene expression	biological_process
GO:0016337	cell-cell adhesion	biological_process
GO:0030097	hemopoiesis	biological_process
GO:0030195	negative regulation of blood coagulation	biological_process
GO:0032720	negative regulation of tumor necrosis factor production	biological_process
GO:0032733	positive regulation of interleukin-10 production	biological_process
GO:0034605	cellular response to heat	biological_process
GO:0035759	mesangial cell-matrix adhesion	biological_process
GO:0038001	paracrine signaling	biological_process
GO:0042482	positive regulation of odontogenesis	biological_process
GO:0045019	negative regulation of nitric oxide biosynthetic process	biological_process
GO:0045766	positive regulation of angiogenesis	biological_process
GO:0048870	cell motility	biological_process
GO:0050776	regulation of immune response	biological_process
GO:0050900	leukocyte migration	biological_process
GO:0060290	transdifferentiation	biological_process
GO:0060547	negative regulation of necrotic cell death	biological_process
GO:0061042	vascular wound healing	biological_process
GO:0070970	interleukin-2 secretion	biological_process
GO:0071425	hemopoietic stem cell proliferation	biological_process
GO:0071456	cellular response to hypoxia	biological_process
GO:0071636	positive regulation of transforming growth factor beta production	biological_process
GO:0071657	positive regulation of granulocyte colony-stimulating factor production	biological_process
GO:0071971	extracellular vesicular exosome assembly	biological_process
GO:0072011	glomerular endothelium development	biological_process
GO:0072089	stem cell proliferation	biological_process
GO:0072254	metanephric glomerular mesangial cell differentiation	biological_process
GO:2001214	positive regulation of vasculogenesis	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005764	lysosome	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0005887	integral to plasma membrane	cellular_component
GO:0009897	external side of plasma membrane	cellular_component
GO:0009925	basal plasma membrane	cellular_component
GO:0016020	membrane	cellular_component
GO:0016324	apical plasma membrane	cellular_component
GO:0045171	intercellular bridge	cellular_component
GO:0048471	perinuclear region of cytoplasm	cellular_component
GO:0008134	transcription factor binding	molecular_function
GO:0030246	carbohydrate binding	molecular_function
GO:0043199	sulfate binding	molecular_function
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