CD163 molecule
Symbol
CD163
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| Cd163 | Mus musculus | |
| Cd163 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2272 | CD163 molecule increases with age | Molecular | hippocampus | Human | CD163 | 515.7% Increase Gene Expression Level | |
| DAA2273 | CD163 molecule increases with age | Molecular | hippocampus | Human | CD163 | 552.3% Increase Gene Expression Level | |
| DAA2279 | CD163 molecule increases with age | Molecular | parietal lobe | Human | CD163 | 488.1% Increase Gene Expression Level | |
| DAA2280 | CD163 molecule increases with age | Molecular | parietal lobe | Human | CD163 | 491.5% Increase Gene Expression Level | |
| DAA2287 | CD163 molecule increases with age | Molecular | frontal lobe | Human | CD163 | 283.0% Increase Gene Expression Level | |
| DAA2288 | CD163 molecule increases with age | Molecular | frontal lobe | Human | CD163 | 383.1% Increase Gene Expression Level |
Changes associated with the orthologs of this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006953 | acute-phase response | biological_process | |
| GO:0006954 | inflammatory response | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0005044 | scavenger receptor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |