CD14 molecule

Symbol

CD14 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

Orthologs

Symbol	Species
Cd14	Mus musculus
Cd14	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data
DAA2204	CD14 molecule increases with age	Molecular	temporal lobe	Human	CD14	154.3% Increase Gene Expression Level
DAA2207	CD14 molecule increases with age	Molecular	hippocampus	Human	CD14	395.0% Increase Gene Expression Level
DAA2221	CD14 molecule increases with age	Molecular	parietal lobe	Human	CD14	186.5% Increase Gene Expression Level
DAA2236	CD14 molecule increases with age	Molecular	frontal lobe	Human	CD14	134.9% Increase Gene Expression Level
DAA3038	Gene expression of CD14 decreases with age	Molecular	skin	Human	CD14	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006909	phagocytosis	biological_process
GO:0006915	apoptotic process	biological_process
GO:0006954	inflammatory response	biological_process
GO:0007166	cell surface receptor linked signaling pathway	biological_process
GO:0008063	Toll signaling pathway	biological_process
GO:0009408	response to heat	biological_process
GO:0032496	response to lipopolysaccharide	biological_process
GO:0032760	positive regulation of tumor necrosis factor production	biological_process
GO:0045087	innate immune response	biological_process
GO:0050715	positive regulation of cytokine secretion	biological_process
GO:0071222	cellular response to lipopolysaccharide	biological_process
GO:0071223	cellular response to lipoteichoic acid	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005615	extracellular space	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0009986	cell surface	cellular_component
GO:0031225	anchored to membrane	cellular_component
GO:0045121	membrane raft	cellular_component
GO:0001530	lipopolysaccharide binding	molecular_function
GO:0001847	opsonin receptor activity	molecular_function
GO:0016019	peptidoglycan receptor activity	molecular_function
GO:0070891	lipoteichoic acid binding	molecular_function
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