activin A receptor, type IB

Symbol

ACVR1B (may also be known as: None)

Organism

Human

Description

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Orthologs

Symbol	Species
LOC559222	Danio rerio
Acvr1b	Mus musculus
Acvr1b	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2062	activin A receptor, type IB increases with age	Molecular	ovary	Human	ACVR1B	51.0% Increase Gene Expression Level
DAA2977	Gene expression of ACVR1B increases with age	Molecular	skin	Human	ACVR1B	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000082	G1/S transition of mitotic cell cycle	biological_process
GO:0001701	in utero embryonic development	biological_process
GO:0001942	hair follicle development	biological_process
GO:0006355	regulation of transcription, DNA-dependent	biological_process
GO:0006468	protein phosphorylation	biological_process
GO:0006917	induction of apoptosis	biological_process
GO:0007165	signal transduction	biological_process
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	biological_process
GO:0007417	central nervous system development	biological_process
GO:0009790	embryo development	biological_process
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	biological_process
GO:0018107	peptidyl-threonine phosphorylation	biological_process
GO:0030308	negative regulation of cell growth	biological_process
GO:0032924	activin receptor signaling pathway	biological_process
GO:0032927	positive regulation of activin receptor signaling pathway	biological_process
GO:0045648	positive regulation of erythrocyte differentiation	biological_process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_process
GO:0046545	development of primary female sexual characteristics	biological_process
GO:0046777	protein autophosphorylation	biological_process
GO:0005886	plasma membrane	cellular_component
GO:0005887	integral to plasma membrane	cellular_component
GO:0009986	cell surface	cellular_component
GO:0016020	membrane	cellular_component
GO:0048179	activin receptor complex	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0004674	protein serine/threonine kinase activity	molecular_function
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	molecular_function
GO:0004702	receptor signaling protein serine/threonine kinase activity	molecular_function
GO:0004872	receptor activity	molecular_function
GO:0005024	transforming growth factor beta-activated receptor activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005524	ATP binding	molecular_function
GO:0016361	activin receptor activity, type I	molecular_function
GO:0017002	activin-activated receptor activity	molecular_function
GO:0019838	growth factor binding	molecular_function
GO:0031625	ubiquitin protein ligase binding	molecular_function
GO:0034711	inhibin binding	molecular_function
GO:0046332	SMAD binding	molecular_function
GO:0046872	metal ion binding	molecular_function
GO:0048185	activin binding	molecular_function
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