adaptor-related protein complex 1, sigma 2 subunit

Symbol

AP1S2 (may also be known as: None)

Organism

Human

Description

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Orthologs

Symbol	Species
ap1s2	Danio rerio
Ap1s2	Mus musculus
Ap1s2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA3516	Gene expression of AP1S2 decreases with age	Molecular	skin	Human	AP1S2	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006886	intracellular protein transport	biological_process
GO:0006892	post-Golgi vesicle-mediated transport	biological_process
GO:0006897	endocytosis	biological_process
GO:0016032	viral reproduction	biological_process
GO:0016044	cellular membrane organization	biological_process
GO:0016192	vesicle-mediated transport	biological_process
GO:0050690	regulation of defense response to virus by virus	biological_process
GO:0000139	Golgi membrane	cellular_component
GO:0005765	lysosomal membrane	cellular_component
GO:0005794	Golgi apparatus	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005905	coated pit	cellular_component
GO:0016020	membrane	cellular_component
GO:0030117	membrane coat	cellular_component
GO:0030119	AP-type membrane coat adaptor complex	cellular_component
GO:0030659	cytoplasmic vesicle membrane	cellular_component
GO:0031410	cytoplasmic vesicle	cellular_component
GO:0008565	protein transporter activity	molecular_function
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