aldehyde dehydrogenase 1 family, member A2

Symbol

ALDH1A2 (may also be known as: None)

Organism

Human

Description

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

Orthologs

SymbolSpecies
aldh1a2 Danio rerio
Aldh1a2 Mus musculus
Aldh1a2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2850 Gene expression of ALDH1A2 increases with age Molecular adipose tissue Human ALDH1A2 —

GO Terms

GO IDGO TermGO Category
GO:0001568 blood vessel development biological_process
GO:0001822 kidney development biological_process
GO:0001889 liver development biological_process
GO:0001936 regulation of endothelial cell proliferation biological_process
GO:0003007 heart morphogenesis biological_process
GO:0006776 vitamin A metabolic process biological_process
GO:0007494 midgut development biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009855 determination of bilateral symmetry biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0009954 proximal/distal pattern formation biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0014032 neural crest cell development biological_process
GO:0016331 morphogenesis of embryonic epithelium biological_process
GO:0021915 neural tube development biological_process
GO:0021983 pituitary gland development biological_process
GO:0030182 neuron differentiation biological_process
GO:0030324 lung development biological_process
GO:0030900 forebrain development biological_process
GO:0030902 hindbrain development biological_process
GO:0031016 pancreas development biological_process
GO:0031076 embryonic camera-type eye development biological_process
GO:0032355 response to estradiol stimulus biological_process
GO:0033189 response to vitamin A biological_process
GO:0034097 response to cytokine stimulus biological_process
GO:0035115 embryonic forelimb morphogenesis biological_process
GO:0042573 retinoic acid metabolic process biological_process
GO:0042574 retinal metabolic process biological_process
GO:0042904 9-cis-retinoic acid biosynthetic process biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0048384 retinoic acid receptor signaling pathway biological_process
GO:0048566 embryonic digestive tract development biological_process
GO:0060324 face development biological_process
GO:0071300 cellular response to retinoic acid biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0001758 retinal dehydrogenase activity molecular_function
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function
GO:0016918 retinal binding molecular_function