cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Symbol

CDK5R1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
Cdk5alpha	Drosophila melanogaster
cdk5r1b	Danio rerio
Cdk5r1	Mus musculus
Cdk5r1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2423	cyclin-dependent kinase 5; regulatory subunit 1 decreases with age	Molecular	dermis	Human	CDK5R1	17.2% Decrease DNA Methylation

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GO Terms

GO ID	GO Term	GO Category
GO:0000079	regulation of cyclin-dependent protein kinase activity	biological_process
GO:0001764	neuron migration	biological_process
GO:0006468	protein phosphorylation	biological_process
GO:0007158	neuron cell-cell adhesion	biological_process
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	biological_process
GO:0007411	axon guidance	biological_process
GO:0007413	axonal fasciculation	biological_process
GO:0007420	brain development	biological_process
GO:0008283	cell proliferation	biological_process
GO:0009790	embryo development	biological_process
GO:0016310	phosphorylation	biological_process
GO:0018105	peptidyl-serine phosphorylation	biological_process
GO:0018107	peptidyl-threonine phosphorylation	biological_process
GO:0021799	cerebral cortex radially oriented cell migration	biological_process
GO:0030182	neuron differentiation	biological_process
GO:0031175	neuron projection development	biological_process
GO:0032956	regulation of actin cytoskeleton organization	biological_process
GO:0035235	ionotropic glutamate receptor signaling pathway	biological_process
GO:0043525	positive regulation of neuron apoptosis	biological_process
GO:0045664	regulation of neuron differentiation	biological_process
GO:0045892	negative regulation of transcription, DNA-dependent	biological_process
GO:0048013	ephrin receptor signaling pathway	biological_process
GO:0061001	regulation of dendritic spine morphogenesis	biological_process
GO:0070507	regulation of microtubule cytoskeleton organization	biological_process
GO:0071902	positive regulation of protein serine/threonine kinase activity	biological_process
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0014069	postsynaptic density	cellular_component
GO:0016020	membrane	cellular_component
GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex	cellular_component
GO:0030424	axon	cellular_component
GO:0030425	dendrite	cellular_component
GO:0030426	growth cone	cellular_component
GO:0031594	neuromuscular junction	cellular_component
GO:0043025	neuronal cell body	cellular_component
GO:0043197	dendritic spine	cellular_component
GO:0043292	contractile fiber	cellular_component
GO:0048471	perinuclear region of cytoplasm	cellular_component
GO:0004672	protein kinase activity	molecular_function
GO:0005509	calcium ion binding	molecular_function
GO:0005515	protein binding	molecular_function
GO:0016301	kinase activity	molecular_function
GO:0016534	cyclin-dependent protein kinase 5 activator activity	molecular_function
GO:0019901	protein kinase binding	molecular_function
GO:0043539	protein serine/threonine kinase activator activity	molecular_function
GO:0045296	cadherin binding	molecular_function
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