cellular repressor of E1A-stimulated genes 1

Symbol

CREG1 (may also be known as: None)

Organism

Human

Description

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
creg1 Danio rerio
Creg1 Mus musculus
Creg1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3506 Gene expression of CREG1 decreases with age Molecular skin Human CREG1 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1705 cellular repressor of E1A-stimulated genes 1 Molecular lung Mouse Creg1 3.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0007275 multicellular organismal development biological_process
GO:0008283 cell proliferation biological_process
GO:0040008 regulation of growth biological_process
GO:0005576 extracellular region cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0003714 transcription corepressor activity molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0010181 FMN binding molecular_function
GO:0016491 oxidoreductase activity molecular_function