basic helix-loop-helix family, member e40

Symbol

BHLHE40 (may also be known as: None)

Organism

Human

Description

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Orthologs

Symbol	Species
bhlhe40	Danio rerio
Bhlhe40	Mus musculus
Bhlhe40	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2847	Gene expression of BHLHE40 decreases with age	Molecular	adipose tissue	Human	BHLHE40	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_process
GO:0006355	regulation of transcription, DNA-dependent	biological_process
GO:0006366	transcription from RNA polymerase II promoter	biological_process
GO:0009416	response to light stimulus	biological_process
GO:0032922	circadian regulation of gene expression	biological_process
GO:0043153	entrainment of circadian clock by photoperiod	biological_process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological_process
GO:0048168	regulation of neuronal synaptic plasticity	biological_process
GO:0005634	nucleus	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0005794	Golgi apparatus	cellular_component
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	molecular_function
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular_function
GO:0001102	RNA polymerase II activating transcription factor binding	molecular_function
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	molecular_function
GO:0003677	DNA binding	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular_function
GO:0003705	sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0019904	protein domain specific binding	molecular_function
GO:0042803	protein homodimerization activity	molecular_function
GO:0043425	bHLH transcription factor binding	molecular_function
GO:0043426	MRF binding	molecular_function
GO:0046982	protein heterodimerization activity	molecular_function
GO:0070888	E-box binding	molecular_function
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