basic helix-loop-helix family, member e40

Symbol

BHLHE40 (may also be known as: None)

Organism

Human

Description

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Orthologs

SymbolSpecies
bhlhe40 Danio rerio
Bhlhe40 Mus musculus
Bhlhe40 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2847 Gene expression of BHLHE40 decreases with age Molecular adipose tissue Human BHLHE40 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0009416 response to light stimulus biological_process
GO:0032922 circadian regulation of gene expression biological_process
GO:0043153 entrainment of circadian clock by photoperiod biological_process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0048168 regulation of neuronal synaptic plasticity biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity molecular_function
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription molecular_function
GO:0001102 RNA polymerase II activating transcription factor binding molecular_function
GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0043425 bHLH transcription factor binding molecular_function
GO:0043426 MRF binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0070888 E-box binding molecular_function