ALG13, UDP-N-acetylglucosaminyltransferase subunit

Symbol

ALG13 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Orthologs

SymbolSpecies
otu Drosophila melanogaster
alg13 Danio rerio
Alg13 Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2114 asparagine-linked glycosylation 13 homolog (S. cerevisiae) decreases with age Molecular ovary Human ALG13 42.2% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process biological_process
GO:0018279 protein N-linked glycosylation via asparagine biological_process
GO:0030259 lipid glycosylation biological_process
GO:0043687 post-translational protein modification biological_process
GO:0044267 cellular protein metabolic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity molecular_function
GO:0016758 transferase activity, transferring hexosyl groups molecular_function
GO:0030246 carbohydrate binding molecular_function