ubiquitin-conjugating enzyme E2D 2

Symbol

UBE2D2 (may also be known as: None)

Organism

Human

Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ube2d2l Danio rerio
Ube2d2 Mus musculus
Ube2d2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2080 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) decreases with age Molecular ovary Human UBE2D2 48.2% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006464 protein modification process biological_process
GO:0006511 ubiquitin-dependent protein catabolic process biological_process
GO:0016567 protein ubiquitination biological_process
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0070936 protein K48-linked ubiquitination biological_process
GO:0000166 nucleotide binding molecular_function
GO:0004842 ubiquitin-protein ligase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0016881 acid-amino acid ligase activity molecular_function