transforming growth factor, beta-induced, 68kDa

Symbol

TGFBI (may also be known as: None)

Organism

Human

Description

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
tgfbi	Danio rerio
Tgfbi	Mus musculus
Tgfbi	Rattus norvegicus
SPAC22H12.05c	Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA3431	Gene expression of TGFBI increases with age	Molecular	skin	Human	TGFBI	—

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GO Terms

GO ID	GO Term	GO Category
GO:0001525	angiogenesis	biological_process
GO:0002062	chondrocyte differentiation	biological_process
GO:0007155	cell adhesion	biological_process
GO:0007162	negative regulation of cell adhesion	biological_process
GO:0007601	visual perception	biological_process
GO:0008283	cell proliferation	biological_process
GO:0030198	extracellular matrix organization	biological_process
GO:0050896	response to stimulus	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005604	basement membrane	cellular_component
GO:0005615	extracellular space	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0031012	extracellular matrix	cellular_component
GO:0005178	integrin binding	molecular_function
GO:0050840	extracellular matrix binding	molecular_function
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