brevican

Symbol

BCAN (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Orthologs

SymbolSpecies
bcan Danio rerio
Bcan Mus musculus
Bcan Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4051 Gene expression of BCAN decreases with age Molecular skin Human BCAN —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1458 brevican Molecular kidney Mouse Bcan 6.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0007155 cell adhesion biological_process
GO:0021766 hippocampus development biological_process
GO:0048168 regulation of neuronal synaptic plasticity biological_process
GO:0005576 extracellular region cellular_component
GO:0005578 proteinaceous extracellular matrix cellular_component
GO:0005615 extracellular space cellular_component
GO:0005624 membrane fraction cellular_component
GO:0016020 membrane cellular_component
GO:0030425 dendrite cellular_component
GO:0031225 anchored to membrane cellular_component
GO:0045202 synapse cellular_component
GO:0005488 binding molecular_function
GO:0005529 sugar binding molecular_function
GO:0005540 hyaluronic acid binding molecular_function