B-cell CLL/lymphoma 6

Symbol

BCL6 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Orthologs

SymbolSpecies
bcl6a Danio rerio
Bcl6 Mus musculus
Bcl6 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2783 Gene expression of BCL6 decreases with age Molecular adipose tissue Human BCL6 —
DAA3009 Gene expression of BCL6 increases with age Molecular skin Human BCL6 —

GO Terms

GO IDGO TermGO Category
GO:0000060 protein import into nucleus, translocation biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000902 cell morphogenesis biological_process
GO:0001953 negative regulation of cell-matrix adhesion biological_process
GO:0002467 germinal center formation biological_process
GO:0002634 regulation of germinal center formation biological_process
GO:0002829 negative regulation of type 2 immune response biological_process
GO:0002903 negative regulation of B cell apoptosis biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0007283 spermatogenesis biological_process
GO:0008104 protein localization biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0030036 actin cytoskeleton organization biological_process
GO:0030183 B cell differentiation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030890 positive regulation of B cell proliferation biological_process
GO:0032319 regulation of Rho GTPase activity biological_process
GO:0032764 negative regulation of mast cell cytokine production biological_process
GO:0035024 negative regulation of Rho protein signal transduction biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043380 regulation of memory T cell differentiation biological_process
GO:0045596 negative regulation of cell differentiation biological_process
GO:0045629 negative regulation of T-helper 2 cell differentiation biological_process
GO:0045749 negative regulation of S phase of mitotic cell cycle biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0048294 negative regulation of isotype switching to IgE isotypes biological_process
GO:0048821 erythrocyte development biological_process
GO:0050727 regulation of inflammatory response biological_process
GO:0050776 regulation of immune response biological_process
GO:0051272 positive regulation of cellular component movement biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005657 replication fork cellular_component
GO:0005730 nucleolus cellular_component
GO:0003676 nucleic acid binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0031490 chromatin DNA binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0046872 metal ion binding molecular_function