v-rel reticuloendotheliosis viral oncogene homolog A (avian)


RELA (may also be known as: None)




NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]


Dif Drosophila melanogaster
rela Danio rerio
Rela Mus musculus
Rela Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001889 liver development biological_process
GO:0001942 hair follicle development biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0006117 acetaldehyde metabolic process biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006952 defense response biological_process
GO:0006954 inflammatory response biological_process
GO:0006968 cellular defense response biological_process
GO:0007568 aging biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0009612 response to mechanical stimulus biological_process
GO:0009617 response to bacterium biological_process
GO:0009887 organ morphogenesis biological_process
GO:0010033 response to organic substance biological_process
GO:0010035 response to inorganic substance biological_process
GO:0010224 response to UV-B biological_process
GO:0014040 positive regulation of Schwann cell differentiation biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0031293 membrane protein intracellular domain proteolysis biological_process
GO:0032332 positive regulation of chondrocyte differentiation biological_process
GO:0032495 response to muramyl dipeptide biological_process
GO:0032570 response to progesterone stimulus biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0033590 response to cobalamin biological_process
GO:0034097 response to cytokine stimulus biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0042177 negative regulation of protein catabolic process biological_process
GO:0042493 response to drug biological_process
GO:0042542 response to hydrogen peroxide biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043200 response to amino acid stimulus biological_process
GO:0043278 response to morphine biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045084 positive regulation of interleukin-12 biosynthetic process biological_process
GO:0045087 innate immune response biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046627 negative regulation of insulin receptor signaling pathway biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0050727 regulation of inflammatory response biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051591 response to cAMP biological_process
GO:0051607 defense response to virus biological_process
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway biological_process
GO:0070555 response to interleukin-1 biological_process
GO:0071222 cellular response to lipopolysaccharide biological_process
GO:0071347 cellular response to interleukin-1 biological_process
GO:0071356 cellular response to tumor necrosis factor biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0043234 protein complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0033613 activating transcription factor binding molecular_function
GO:0042301 phosphate ion binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0047485 protein N-terminus binding molecular_function
GO:0051059 NF-kappaB binding molecular_function
GO:0070491 repressing transcription factor binding molecular_function
GO:0071532 ankyrin repeat binding molecular_function