angiotensin I converting enzyme 2
Symbol
ACE2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| acn-1 | Caenorhabditis elegans | |
| Ance-3 | Drosophila melanogaster | |
| ace2 | Danio rerio | |
| Ace2 | Mus musculus | |
| Ace2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2914 | Gene expression of ACE2 increases with age | Molecular | adipose tissue | Human | ACE2 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001817 | regulation of cytokine production | biological_process | |
| GO:0002005 | angiotensin catabolic process in blood | biological_process | |
| GO:0003051 | angiotensin-mediated drinking behavior | biological_process | |
| GO:0003081 | regulation of systemic arterial blood pressure by renin-angiotensin | biological_process | |
| GO:0006508 | proteolysis | biological_process | |
| GO:0009615 | response to virus | biological_process | |
| GO:0019229 | regulation of vasoconstriction | biological_process | |
| GO:0032800 | receptor biosynthetic process | biological_process | |
| GO:0042127 | regulation of cell proliferation | biological_process | |
| GO:0042312 | regulation of vasodilation | biological_process | |
| GO:0044419 | interspecies interaction between organisms | biological_process | |
| GO:0046718 | entry of virus into host cell | biological_process | |
| GO:0046813 | virion attachment, binding of host cell surface receptor | biological_process | |
| GO:0050727 | regulation of inflammatory response | biological_process | |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0009986 | cell surface | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0045121 | membrane raft | cellular_component | |
| GO:0001618 | viral receptor activity | molecular_function | |
| GO:0001948 | glycoprotein binding | molecular_function | |
| GO:0004175 | endopeptidase activity | molecular_function | |
| GO:0004180 | carboxypeptidase activity | molecular_function | |
| GO:0008233 | peptidase activity | molecular_function | |
| GO:0008237 | metallopeptidase activity | molecular_function | |
| GO:0008241 | peptidyl-dipeptidase activity | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |