mitogen-activated protein kinase kinase 1

Symbol

MAP2K1 (may also be known as: MEK1, MAPK)

Organism

Human

Orthologs

Symbol	Species
mek-2	Caenorhabditis elegans
map2k1	Danio rerio
Map2k1	Mus musculus
Map2k1	Rattus norvegicus
byr1	Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA130	mitogen-activated protein kinase kinase 1	Molecular	brain	Human	MAP2K1	7.0% Decrease Gene Expression Level

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GO Terms

GO ID	GO Term	GO Category
GO:0000165	MAPKKK cascade	biological_process
GO:0000186	activation of MAPKK activity	biological_process
GO:0000187	activation of MAPK activity	biological_process
GO:0002224	toll-like receptor signaling pathway	biological_process
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological_process
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological_process
GO:0003056	regulation of vascular smooth muscle contraction	biological_process
GO:0006928	cellular component movement	biological_process
GO:0006935	chemotaxis	biological_process
GO:0006979	response to oxidative stress	biological_process
GO:0007050	cell cycle arrest	biological_process
GO:0007067	mitosis	biological_process
GO:0007165	signal transduction	biological_process
GO:0007173	epidermal growth factor receptor signaling pathway	biological_process
GO:0007264	small GTPase mediated signal transduction	biological_process
GO:0007265	Ras protein signal transduction	biological_process
GO:0007411	axon guidance	biological_process
GO:0008063	Toll signaling pathway	biological_process
GO:0008285	negative regulation of cell proliferation	biological_process
GO:0008286	insulin receptor signaling pathway	biological_process
GO:0008543	fibroblast growth factor receptor signaling pathway	biological_process
GO:0030182	neuron differentiation	biological_process
GO:0030216	keratinocyte differentiation	biological_process
GO:0030335	positive regulation of cell migration	biological_process
GO:0032320	positive regulation of Ras GTPase activity	biological_process
GO:0032402	melanosome transport	biological_process
GO:0032872	regulation of stress-activated MAPK cascade	biological_process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	biological_process
GO:0034111	negative regulation of homotypic cell-cell adhesion	biological_process
GO:0034130	toll-like receptor 1 signaling pathway	biological_process
GO:0034134	toll-like receptor 2 signaling pathway	biological_process
GO:0034138	toll-like receptor 3 signaling pathway	biological_process
GO:0034142	toll-like receptor 4 signaling pathway	biological_process
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological_process
GO:0045087	innate immune response	biological_process
GO:0045597	positive regulation of cell differentiation	biological_process
GO:0046579	positive regulation of Ras protein signal transduction	biological_process
GO:0047496	vesicle transport along microtubule	biological_process
GO:0048011	nerve growth factor receptor signaling pathway	biological_process
GO:0048678	response to axon injury	biological_process
GO:0048812	neuron projection morphogenesis	biological_process
GO:0048870	cell motility	biological_process
GO:0051384	response to glucocorticoid stimulus	biological_process
GO:0051403	stress-activated MAPK cascade	biological_process
GO:0060674	placenta blood vessel development	biological_process
GO:0060711	labyrinthine layer development	biological_process
GO:0090170	regulation of Golgi inheritance	biological_process
GO:0090398	cellular senescence	biological_process
GO:2000641	regulation of early endosome to late endosome transport	biological_process
GO:0005625	soluble fraction	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005739	mitochondrion	cellular_component
GO:0005769	early endosome	cellular_component
GO:0005770	late endosome	cellular_component
GO:0005794	Golgi apparatus	cellular_component
GO:0005816	spindle pole body	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005856	cytoskeleton	cellular_component
GO:0005874	microtubule	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0005925	focal adhesion	cellular_component
GO:0005938	cell cortex	cellular_component
GO:0032839	dendrite cytoplasm	cellular_component
GO:0033267	axon part	cellular_component
GO:0043204	perikaryon	cellular_component
GO:0048471	perinuclear region of cytoplasm	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0004672	protein kinase activity	molecular_function
GO:0004674	protein serine/threonine kinase activity	molecular_function
GO:0004708	MAP kinase kinase activity	molecular_function
GO:0004712	protein serine/threonine/tyrosine kinase activity	molecular_function
GO:0004713	protein tyrosine kinase activity	molecular_function
GO:0004728	receptor signaling protein tyrosine phosphatase activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005524	ATP binding	molecular_function
GO:0017016	Ras GTPase binding	molecular_function
GO:0031435	mitogen-activated protein kinase kinase kinase binding	molecular_function
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