acyl-CoA synthetase short-chain family member 2

Symbol

ACSS2 (may also be known as: None)

Organism

Human

Description

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

Orthologs

SymbolSpecies
acs-19 Caenorhabditis elegans
AcCoAS Drosophila melanogaster
acss2 Danio rerio
Acss2 Mus musculus
Acss2 Rattus norvegicus
ACS1 Saccharomyces cerevisiae
SPCC191.02c Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2908 Gene expression of ACSS2 decreases with age Molecular adipose tissue Human ACSS2 —
DAA3974 Gene expression of ACSS2 decreases with age Molecular skin Human ACSS2 —

GO Terms

GO IDGO TermGO Category
GO:0006069 ethanol oxidation biological_process
GO:0006085 acetyl-CoA biosynthetic process biological_process
GO:0006805 xenobiotic metabolic process biological_process
GO:0008610 lipid biosynthetic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003824 catalytic activity molecular_function
GO:0003987 acetate-CoA ligase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016208 AMP binding molecular_function
GO:0016874 ligase activity molecular_function