acyl-CoA synthetase short-chain family member 2
Symbol
ACSS2
(may also be known as: None)
Organism
Human
Description
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Orthologs
Symbol | Species | |
---|---|---|
acs-19 | Caenorhabditis elegans | |
AcCoAS | Drosophila melanogaster | |
acss2 | Danio rerio | |
Acss2 | Mus musculus | |
Acss2 | Rattus norvegicus | |
ACS1 | Saccharomyces cerevisiae | |
SPCC191.02c | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2908 | Gene expression of ACSS2 decreases with age | Molecular | adipose tissue | Human | ACSS2 | — | |
DAA3974 | Gene expression of ACSS2 decreases with age | Molecular | skin | Human | ACSS2 | — |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0006069 | ethanol oxidation | biological_process | |
GO:0006085 | acetyl-CoA biosynthetic process | biological_process | |
GO:0006805 | xenobiotic metabolic process | biological_process | |
GO:0008610 | lipid biosynthetic process | biological_process | |
GO:0044281 | small molecule metabolic process | biological_process | |
GO:0005634 | nucleus | cellular_component | |
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