ATP-binding cassette, sub-family B (MDR/TAP), member 1

Symbol

ABCB1 (may also be known as: None)

Organism

Human

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Abcb1a Mus musculus
Abcb1a Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3320 Gene expression of ABCB1 increases with age Molecular skin Human ABCB1 —

GO Terms

GO IDGO TermGO Category
GO:0000086 G2/M transition of mitotic cell cycle biological_process
GO:0006810 transport biological_process
GO:0042493 response to drug biological_process
GO:0055085 transmembrane transport biological_process
GO:0072089 stem cell proliferation biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0046581 intercellular canaliculus cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005215 transporter activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008559 xenobiotic-transporting ATPase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function