poly(rC) binding protein 1


PCBP1 (may also be known as: None)




This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]


pes-4 Caenorhabditis elegans
pcbp2 Danio rerio
Pcbp1 Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2075 poly(rC) binding protein 1 increases with age Molecular ovary Human PCBP1 59.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000398 nuclear mRNA splicing, via spliceosome biological_process
GO:0008380 RNA splicing biological_process
GO:0010467 gene expression biological_process
GO:0016071 mRNA metabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0030529 ribonucleoprotein complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0003697 single-stranded DNA binding molecular_function
GO:0003723 RNA binding molecular_function
GO:0005515 protein binding molecular_function