nerve growth factor (beta polypeptide)

Symbol

NGF (may also be known as: None)

Organism

Human

Description

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ntf7 Danio rerio
Ngf Mus musculus
Ngf Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2434 nerve growth factor; beta polypeptide precursor decreases with age Molecular mesenchymal stem cell Human NGF 22.5% Decrease DNA Methylation
DAA2385 nerve growth factor; beta polypeptide precursor increases with age Molecular dermis Human NGF 19.3% Increase DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0000186 activation of MAPKK activity biological_process
GO:0006915 apoptotic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006954 inflammatory response biological_process
GO:0007165 signal transduction biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0007202 activation of phospholipase C activity biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0007265 Ras protein signal transduction biological_process
GO:0007422 peripheral nervous system development biological_process
GO:0007613 memory biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008344 adult locomotory behavior biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0009314 response to radiation biological_process
GO:0009612 response to mechanical stimulus biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0019233 sensory perception of pain biological_process
GO:0031175 neuron projection development biological_process
GO:0031954 positive regulation of protein autophosphorylation biological_process
GO:0032455 nerve growth factor processing biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0035094 response to nicotine biological_process
GO:0042493 response to drug biological_process
GO:0043434 response to peptide hormone stimulus biological_process
GO:0043524 negative regulation of neuron apoptosis biological_process
GO:0045664 regulation of neuron differentiation biological_process
GO:0045773 positive regulation of axon extension biological_process
GO:0045786 negative regulation of cell cycle biological_process
GO:0046928 regulation of neurotransmitter secretion biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048015 phosphatidylinositol-mediated signaling biological_process
GO:0050770 regulation of axonogenesis biological_process
GO:0050772 positive regulation of axonogenesis biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051388 positive regulation of nerve growth factor receptor signaling pathway biological_process
GO:0051602 response to electrical stimulus biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005768 endosome cellular_component
GO:0005788 endoplasmic reticulum lumen cellular_component
GO:0005796 Golgi lumen cellular_component
GO:0005057 receptor signaling protein activity molecular_function
GO:0005163 nerve growth factor receptor binding molecular_function
GO:0008083 growth factor activity molecular_function