MHC class I polypeptide-related sequence B

Symbol

MICB (may also be known as: None)

Organism

Human

Description

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2340	MHC class I polypeptide-related sequence B increases with age	Molecular	parietal lobe	Human	MICB	39.9% Increase Gene Expression Level

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GO Terms

GO ID	GO Term	GO Category
GO:0002429	immune response-activating cell surface receptor signaling pathway	biological_process
GO:0006955	immune response	biological_process
GO:0006979	response to oxidative stress	biological_process
GO:0009408	response to heat	biological_process
GO:0019835	cytolysis	biological_process
GO:0019882	antigen processing and presentation	biological_process
GO:0032526	response to retinoic acid	biological_process
GO:0044419	interspecies interaction between organisms	biological_process
GO:0046629	gamma-delta T cell activation	biological_process
GO:0050689	negative regulation of defense response to virus by host	biological_process
GO:0050776	regulation of immune response	biological_process
GO:0005886	plasma membrane	cellular_component
GO:0005887	integral to plasma membrane	cellular_component
GO:0016020	membrane	cellular_component
GO:0042612	MHC class I protein complex	cellular_component
GO:0046703	natural killer cell lectin-like receptor binding	molecular_function
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