MHC class I polypeptide-related sequence A

Symbol

MICA (may also be known as: None)

Organism

Human

Description

MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2165	MHC class I polypeptide-related sequence A increases with age	Molecular	frontal lobe	Human	MICA	39.5% Increase Gene Expression Level
DAA2348	MHC class I polypeptide-related sequence A increases with age	Molecular	frontal lobe	Human	MICA	37.9% Increase Gene Expression Level

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GO Terms

GO ID	GO Term	GO Category
GO:0002223	stimulatory C-type lectin receptor signaling pathway	biological_process
GO:0002418	immune response to tumor cell	biological_process
GO:0006955	immune response	biological_process
GO:0006974	response to DNA damage stimulus	biological_process
GO:0009408	response to heat	biological_process
GO:0019835	cytolysis	biological_process
GO:0019882	antigen processing and presentation	biological_process
GO:0042742	defense response to bacterium	biological_process
GO:0046629	gamma-delta T cell activation	biological_process
GO:0050776	regulation of immune response	biological_process
GO:0051607	defense response to virus	biological_process
GO:0005615	extracellular space	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0005887	integral to plasma membrane	cellular_component
GO:0009986	cell surface	cellular_component
GO:0016020	membrane	cellular_component
GO:0042612	MHC class I protein complex	cellular_component
GO:0030881	beta-2-microglobulin binding	molecular_function
GO:0046703	natural killer cell lectin-like receptor binding	molecular_function
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