lecithin-cholesterol acyltransferase

Symbol

LCAT (may also be known as: None)

Organism

Human

Description

This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
CELE_M05B5.4	Caenorhabditis elegans
CG18858	Drosophila melanogaster
lcat	Danio rerio
Lcat	Mus musculus
Lcat	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA3243	Gene expression of LCAT increases with age	Molecular	skin	Human	LCAT	—
DAA2425	lecithin-cholesterol acyltransferase precursor decreases with age	Molecular	dermis	Human	LCAT	18.6% Decrease DNA Methylation

First
Last

GO Terms

GO ID	GO Term	GO Category
GO:0006629	lipid metabolic process	biological_process
GO:0006644	phospholipid metabolic process	biological_process
GO:0006656	phosphatidylcholine biosynthetic process	biological_process
GO:0008202	steroid metabolic process	biological_process
GO:0008203	cholesterol metabolic process	biological_process
GO:0030301	cholesterol transport	biological_process
GO:0034372	very-low-density lipoprotein particle remodeling	biological_process
GO:0034375	high-density lipoprotein particle remodeling	biological_process
GO:0034435	cholesterol esterification	biological_process
GO:0042157	lipoprotein metabolic process	biological_process
GO:0042158	lipoprotein biosynthetic process	biological_process
GO:0042632	cholesterol homeostasis	biological_process
GO:0043691	reverse cholesterol transport	biological_process
GO:0044281	small molecule metabolic process	biological_process
GO:0046688	response to copper ion	biological_process
GO:0051384	response to glucocorticoid stimulus	biological_process
GO:0090107	regulation of high-density lipoprotein particle assembly	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005615	extracellular space	cellular_component
GO:0034364	high-density lipoprotein particle	cellular_component
GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	molecular_function
GO:0004623	phospholipase A2 activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0016746	transferase activity, transferring acyl groups	molecular_function
GO:0034186	apolipoprotein A-I binding	molecular_function
▼ Show more GO terms