adenine phosphoribosyltransferase

Symbol

APRT (may also be known as: None)

Organism

Human

Description

Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
T19B4.3 Caenorhabditis elegans
Aprt Drosophila melanogaster
aprt Danio rerio
Aprt Mus musculus
Aprt Rattus norvegicus
APT2 Saccharomyces cerevisiae
apt1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006144 purine base metabolic process biological_process
GO:0006166 purine ribonucleoside salvage biological_process
GO:0006168 adenine salvage biological_process
GO:0007595 lactation biological_process
GO:0007625 grooming behavior biological_process
GO:0009116 nucleoside metabolic process biological_process
Show more GO terms