apolipoprotein E

Symbol

APOE

Organism

Human

Orthologs

SymbolSpecies
apoea Danio rerio
Apoe Mus musculus
Apoe Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1223 APOE promoter methylation decrease Molecular prefrontal cortex Human APOE —

GO Terms

GO IDGO TermGO Category
GO:0000302 response to reactive oxygen species biological_process
GO:0001937 negative regulation of endothelial cell proliferation biological_process
GO:0002021 response to dietary excess biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006641 triglyceride metabolic process biological_process
GO:0006707 cholesterol catabolic process biological_process
GO:0006874 cellular calcium ion homeostasis biological_process
GO:0006898 receptor-mediated endocytosis biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006979 response to oxidative stress biological_process
GO:0007010 cytoskeleton organization biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007263 nitric oxide mediated signal transduction biological_process
GO:0007271 synaptic transmission, cholinergic biological_process
GO:0007568 aging biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0008219 cell death biological_process
GO:0010468 regulation of gene expression biological_process
GO:0010544 negative regulation of platelet activation biological_process
GO:0010873 positive regulation of cholesterol esterification biological_process
GO:0010875 positive regulation of cholesterol efflux biological_process
GO:0014012 peripheral nervous system axon regeneration biological_process
GO:0019934 cGMP-mediated signaling biological_process
GO:0030195 negative regulation of blood coagulation biological_process
GO:0030516 regulation of axon extension biological_process
GO:0030828 positive regulation of cGMP biosynthetic process biological_process
GO:0032488 Cdc42 protein signal transduction biological_process
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process biological_process
GO:0033344 cholesterol efflux biological_process
GO:0033700 phospholipid efflux biological_process
GO:0034372 very-low-density lipoprotein particle remodeling biological_process
GO:0034374 low-density lipoprotein particle remodeling biological_process
GO:0034375 high-density lipoprotein particle remodeling biological_process
GO:0034380 high-density lipoprotein particle assembly biological_process
GO:0034382 chylomicron remnant clearance biological_process
GO:0034384 high-density lipoprotein particle clearance biological_process
GO:0034447 very-low-density lipoprotein particle clearance biological_process
GO:0042157 lipoprotein metabolic process biological_process
GO:0042158 lipoprotein biosynthetic process biological_process
GO:0042159 lipoprotein catabolic process biological_process
GO:0042311 vasodilation biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0043085 positive regulation of catalytic activity biological_process
GO:0043407 negative regulation of MAP kinase activity biological_process
GO:0043537 negative regulation of blood vessel endothelial cell migration biological_process
GO:0043691 reverse cholesterol transport biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045471 response to ethanol biological_process
GO:0045541 negative regulation of cholesterol biosynthetic process biological_process
GO:0046907 intracellular transport biological_process
GO:0048168 regulation of neuronal synaptic plasticity biological_process
GO:0048844 artery morphogenesis biological_process
GO:0050728 negative regulation of inflammatory response biological_process
GO:0051000 positive regulation of nitric-oxide synthase activity biological_process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis biological_process
GO:0051651 maintenance of location in cell biological_process
GO:0055088 lipid homeostasis biological_process
GO:0071363 cellular response to growth factor stimulus biological_process
GO:0072358 cardiovascular system development biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005769 early endosome cellular_component
GO:0005770 late endosome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005874 microtubule cellular_component
GO:0005886 plasma membrane cellular_component
GO:0030425 dendrite cellular_component
GO:0031232 extrinsic to external side of plasma membrane cellular_component
GO:0034361 very-low-density lipoprotein particle cellular_component
GO:0034362 low-density lipoprotein particle cellular_component
GO:0034363 intermediate-density lipoprotein particle cellular_component
GO:0034364 high-density lipoprotein particle cellular_component
GO:0042627 chylomicron cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0001540 beta-amyloid binding molecular_function
GO:0005319 lipid transporter activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005543 phospholipid binding molecular_function
GO:0008201 heparin binding molecular_function
GO:0008289 lipid binding molecular_function
GO:0016209 antioxidant activity molecular_function
GO:0017127 cholesterol transporter activity molecular_function
GO:0042802 identical protein binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0046911 metal chelating activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0048156 tau protein binding molecular_function
GO:0050750 low-density lipoprotein particle receptor binding molecular_function
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity molecular_function
GO:0070326 very-low-density lipoprotein particle receptor binding molecular_function
GO:0071813 lipoprotein particle binding molecular_function