acyl-CoA dehydrogenase, C-4 to C-12 straight chain

Symbol

ACADM (may also be known as: None)

Organism

Human

Description

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
acdh-7 Caenorhabditis elegans
CG12262 Drosophila melanogaster
acadm Danio rerio
Acadm Mus musculus
Acadm Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2970 Gene expression of ACADM decreases with age Molecular skin Human ACADM —

GO Terms

GO IDGO TermGO Category
GO:0001889 liver development biological_process
GO:0005978 glycogen biosynthetic process biological_process
GO:0006082 organic acid metabolic process biological_process
GO:0006111 regulation of gluconeogenesis biological_process
GO:0006635 fatty acid beta-oxidation biological_process
GO:0007507 heart development biological_process
GO:0007584 response to nutrient biological_process
GO:0009409 response to cold biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0009791 post-embryonic development biological_process
GO:0019254 carnitine metabolic process, CoA-linked biological_process
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase biological_process
GO:0042493 response to drug biological_process
GO:0042594 response to starvation biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045329 carnitine biosynthetic process biological_process
GO:0046688 response to copper ion biological_process
GO:0051289 protein homotetramerization biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051791 medium-chain fatty acid metabolic process biological_process
GO:0051793 medium-chain fatty acid catabolic process biological_process
GO:0055007 cardiac muscle cell differentiation biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005739 mitochondrion cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0030424 axon cellular_component
GO:0031966 mitochondrial membrane cellular_component
GO:0000062 fatty-acyl-CoA binding molecular_function
GO:0003995 acyl-CoA dehydrogenase activity molecular_function
GO:0016853 isomerase activity molecular_function
GO:0042802 identical protein binding molecular_function
GO:0043958 acryloyl-CoA reductase activity molecular_function
GO:0050660 flavin adenine dinucleotide binding molecular_function
GO:0070991 medium-chain-acyl-CoA dehydrogenase activity molecular_function